Purpose: Researchers tried to improve the mechanical properties of poly methyl methacrylate
(PMMA) denture bases. Development of alternative materials such as thermoplastic denture base
materials as polyamide had also been reported in the literature, however, it has not been well studied
regarding color stability. The aim of this in vitro study was to evaluate the effect of two different
cleansing agents on color stability of thermoplastic denture base material. Materials and methods:
Thirty samples were fabricated from polyamide (Vertex Thermosens thermoplastic denture base
material). Samples were divided into Three groups: 10 each. Group I (control group): soaked in
distilled water, Group II: soaked in Corega cleansing agent and Group III: soaked in Efferdent
cleansing agent. Results: Statistical non-significant results were found. A slight non-significant
effect on color stability was found more with Efferdent than Corega cleansing agent and water.
Conclusion: Disinfecting polyamide denture base material (Vertex Thermosens) could be done
safely with Corega and Efferdent cleansing agents.