Purpose: This study investigated the effect of platelet rich fibrin (PRF) on zirconia root
analogue dental implant osseointegration by histological analysis.
Material and method: Ten adult male mongrel dogs with split mandible technique were used.
Left side of the mandible received only the implant and used as a control (group1). The right side
received PRF and the implant (group2). Animals were sacrificed at 1 and 3 months. The specimens
were prepared routinely and stained with (H&E) stain for tissue details, and alizarin red stain for
tissue mineralization.
Results: Image analysis of the slides for both groups showed a statistically higher mean bone
formation in PRF group than control /time.
Conclusion: PRF appears to enhance osseointegration of root analogue zirconia dental implant.