Objective: Psychological stress is one of the prime triggering factors for recurrent aphthous ulceration. The goal of this investigation is to measure salivary levels of α-Amylase and Cortisol, as stress biomarkers, in patients with recurrent aphthous ulceration.
Subjects and Methods: Whole unstimulated salivary samples were collected from 25 patients with recurrent aphthous ulceration & 25 healthy controls. Salivary levels of α-Amylase and Cortisol was quantified using enzyme-linked immunosorbent assay (ELISA).
Results: A statistically significant increase in salivary levels of both α-Amylase and Cortisol was detected in recurrent aphthous ulceration patients compared to healthy controls.
Conclusion: Salivary α-Amylase and Cortisol can be used as reliable stress biomarkers in patients with recurrent aphthous ulceration.