Objectives: To investigate the effect of hesperidin application on the bonding of resin-modified glass ionomer-based restorative material to dentin treated with oxygen-induced endodontic irrigants. Materials and Methods: One hundred human permanent molars were categorized into five  groups (n= 20/group), treated with various irrigants as follows: group C; distilled water (negativecontrol), group SH; 5.25% NaOCl (positive control), group SH+H; 5.25% NaOCl + 5 % hesperidin, group HP; 10% H2O2, group HP+H; 10% H2O2 + 5 % hesperidin. Immediately after treatments, the specimens were bonded with the RMGI-based restorative material. For each group, half of the specimens were evaluated for μSBS by a universal testing machine and the other half for elemental analysis by EDX. Additional ten specimens (n=2/group) were prepared for the micromorphological analysis using SEM. Data were analyzed using One-way ANOVA and Tukey's multiple comparison test (P<.05). The fracture pattern was analyzed by the Chi-square (χ2) test. Results: Hesperidin groups improved the μSBS, with a significant effect for HP+H group (P<.05). A significant increase in the ion weight percentages was detected in hesperidin groups (P< .001). Conclusion: Application of hesperidin improved the dentin bond strength and increased the ion weight percentages in dentin alongside RMGI based restorative material; this could be a promising approach to aid dental practitioners in their decisions, regarding which restorative material to use especially in caries susceptible patients.