This study was performed to compare the impact of the sandblasting on the retention of the complete dentures made from two different denture base materials. Materials and methods: Twenty patients were selected to construct complete dentures with the fitting surface treated by sandblasting using alumina particles 50μ in diameter. They were randomly divided into two groups: Group A patients received complete dentures constructed from (poly methyl methacrylate) PMMA long cycle heat cure acrylic resin & Group B: Patients received complete dentures constructed from cadmium-free heat cured acrylic resin. The retention was measured for the two denture base materials (cadmium free and cadmium containing materials before and after sandblasting the fitting surface using Digital force gauge. Results: There was statistically significant increase in the retention values of the cadmium free material than that of the conventional material before and after sandblasting