Objectives: The aim of this study is to compare the effect of Platelet-rich plasma (PRP) and Hyaluronic acid (HA) in management of Temporomandibular joint osteoarthritis (TMJ-OA)
Patients and methods: Among 46 patients who were diagnosed with TMJ-OA, 14 patients were treated with PRP, 17 patients were treated with HA and 15 patients were treated with arthrocentesis alone, evaluation of clinical improvement was done for each patient postoperatively at 6 and 12 months.
Results: After 6 months, there were no statistically significant differences in the mean changes between PRP and HA groups regarding the pain intensity value, joint sound and extent of maximum mouth opening, while at the end of the follow-up period, after 12 months, better clinical results were maintained in the group treated with PRP.
Conclusion: The application of PRP is more effective and remains for long term than HA injection TMJ-OA treatment.