Platelet-rich fibrin (PRF) is a second-generation platelet concentrate which contains platelets and growth factors in the form of fibrin membranes prepared from the patient's own blood free of any anticoagulant or other artificial biochemical modifications. The PRF clot forms a strong natural fibrin matrix, which concentrates almost all the platelets and growth factors of the blood harvest Platelet rich fibrin (PRF) is believed to be a natural alternative with accepted results and minimal risks. PRF has a lot of advantages and indications, because of its minimally invasive technique with low risks and favorable clinical results. PRF can be used as a resorbable membrane because it is a fibrin matrix in which platelet cytokines, growth factors, and cells are trapped and may be released after a certain time. Autologous PRF is a healing biomaterial, and applied in various disciplines of dentistry. The following review attempts to summarize the relevant literature regarding the technique of using PRF, including its preparation, advantages, and disadvantages of using it in clinical applications.