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75971

EFFECT OF ACUTE LYMPHOBLASTIC LEUKEMIA ON SALIVARY ALTERATIONS IN CHILDREN BEFORE AND AFTER CHEMOTHERAPY INDUCTION

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Last updated: 01 Jan 2025

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Abstract

Background: Approximately 2,56,000 children and young adults around the world developed acute lymphoblastic leukemia (ALL) which is the most common subtype of Leukemia. The aim of our study was to investigate the effect of acute lymphoblastic leukemia on salivary alterations in children before and after chemotherapy induction.
Materials and methods: This study included 45 children aged from 5 to 9 years. The sample was divided into 3 groups: Group A (control group); clinically healthy un-medicated children, Group B: children with a previous diagnosis of ALL and did not initiate the chemotherapy treatment and Group C: hospitalized children with a previous diagnosis of ALL and who were on chemotherapy (6 months-1.5 years of treatment). From the selected children, stimulated whole saliva samples were collected in graduated tubes with funnels over a 5 minute period in the morning. Saliva samples were used to determine the stimulated salivary flow rate, salivary pH, salivary total proteins and salivary alpha amylase.
Results: The results showed a significant reduction in the mean of salivary flow rate values between (group A) and (group C), also the difference was significant between (group B) and (group C). Regarding mean pH value, there was a significant difference between the 3 groups with an obvious reduction in pH values of groups B & C. Moreover, the findings showed that the means of salivary total proteins and salivary alpha amylase were significantly higher in group B than in group A and group C.
Conclusion: According to ROC curve analysis salivary total proteins reflect an excellent predictor test where the value of total salivary proteins above 8.381 g/dl indicated ALL leukemia with 100% accuracy in children.

DOI

10.21608/edj.2017.75971

Keywords

Leukemia, Chemotherapy, children- saliva

Authors

First Name

Ghada

Last Name

ElBaz

MiddleName

A.

Affiliation

Associate Professor of Pediatric and Preventive Dentistry and Dental Public Health, Faculty of Dentistry, Suez Canal University.

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Orcid

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First Name

Rana

Last Name

Shalaby

MiddleName

A.

Affiliation

Assistant Lecturer of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Fayoum University.

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City

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Orcid

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Volume

63

Article Issue

Issue 4 - October (Orthodontics, Pediatric & Preventive Dentistry)

Related Issue

11154

Issue Date

2017-10-01

Receive Date

2020-03-06

Publish Date

2017-10-01

Page Start

2,915

Page End

2,921

Print ISSN

0070-9484

Online ISSN

2090-2360

Link

https://edj.journals.ekb.eg/article_75971.html

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https://edj.journals.ekb.eg/service?article_code=75971

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Original Article

Type Code

254

Publication Type

Journal

Publication Title

Egyptian Dental Journal

Publication Link

https://edj.journals.ekb.eg/

MainTitle

EFFECT OF ACUTE LYMPHOBLASTIC LEUKEMIA ON SALIVARY ALTERATIONS IN CHILDREN BEFORE AND AFTER CHEMOTHERAPY INDUCTION

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Article

Created At

22 Jan 2023