74552

EVALUATION OF BCL-2 EXPRESSION IN CIGARETTE SMOKERS

Article

Last updated: 01 Jan 2025

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Abstract

Background: Tobacco use is the most important risk factor linked to oral cancer. Tobacco influences the DNA repair, cell cycle control, proliferation and apoptosis. The present study observed bcl-2 expression to verify its value as prognostic markers in cigarette smokers.
Methods: The study sample comprised 40 smoking males; 20 with hyperplasia and 20 with dysplasia. The duration of smoking and the number of cigarettes were recorded. Hematoxylene and Eosin stained sections were used for histopathologic examination and immunostained sections for evaluation of the expression of bcl-2. The resulting data were analyzed statistically.
Results: The dysplasia group had a higher mean duration of smoking, number of cigarettes per day and total number of cigarettes as well as higher mean area % and stronger bcl-2 immunoreactions compared to that of the hyperplasia group.
Conclusions: Bcl-2 may be a valuable prognostic marker in evaluating the malignant potential of hyperplastic and dysplastic lesions in cigarette smokers.

DOI

10.21608/edj.2017.74552

Keywords

Bcl-2, cigarette smokers, oral cancer

Authors

First Name

Shereen

Last Name

Ali

MiddleName

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Affiliation

Lecturer, Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Lecturer, Department of Oral Medicine, Periodontology and Oral Radiology, Faculty of Dentistry, Misr International University (MIU).

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Volume

63

Article Issue

Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)

Related Issue

11148

Issue Date

2017-04-01

Receive Date

2020-02-29

Publish Date

2017-04-01

Page Start

1,551

Page End

1,558

Print ISSN

0070-9484

Online ISSN

2090-2360

Link

https://edj.journals.ekb.eg/article_74552.html

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https://edj.journals.ekb.eg/service?article_code=74552

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15

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Original Article

Type Code

254

Publication Type

Journal

Publication Title

Egyptian Dental Journal

Publication Link

https://edj.journals.ekb.eg/

MainTitle

EVALUATION OF BCL-2 EXPRESSION IN CIGARETTE SMOKERS

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Article

Created At

22 Jan 2023