Background: Augmentation of localized alveolar bone defect is one of major problems in implant dentistry. Beta tri-calcium phosphate (β-TCP) is considered a source of synthetic bone substitute for bone regeneration. If it is combined with platelet rich fibrin (PRF) with immediately placed dental implant it may encounter a promising result for bone formation.
Objective: The aim of the present study was to compare the regenerative bone potential around immediately placed dental implant in localized alveolar bony defect by the use of β-TCP alone or in combination with PRF.
Materials and Methods: Eight clinically healthy dogs were included in this study. Localized alveolar bone defect was created after extraction of the second mandibular premolar bilaterally. After immediate implants were inserted the defect was augmented with following: Group I: β-TCP. Group II: β-TCP with PRF. Group III: Control group without adding any material.
After 12 weeks, the animals were sacrificed and bone regeneration in the created defect was evaluated through histological examination, immunohistochemically and histomorphometric
analysis.
Results: Groups analysis demonstrated signs of bone regeneration with variable degrees. Histomorphometrically, the control group revealed the lowest mean area percentage. Group I: β-TCP and group II: β-TCP combined with PRF showed the highest mean area percentage and both were significantly higher than control group. However, no significant difference observed between group I and II. The results were supported by both histological and immunohistochemical analysis. The signs of bone maturation in group I & group II were more than control group.
Conclusion: Beta tri-calcium phosphate with platelet rich fibrin is a promising osteogenic bone substitute with high bone regenerative potential .It could be used as an alternative method for bone regeneration around dental implant in localized alveolar bone defect.