Objectives: The aim of the present in vitro study was to evaluate the effect of “Casein phosphopeptide amorphous calcium phosphate" (MI) and “Casein phosphopeptide amorphous calcium phosphate with fluoride" (MI plus) pastes on dental enamel exposed to three different oral pediatric medications using Vickers microhardness test and scanning electron microscope (SEM).
Methods: One hundred extracted caries free human permanent teeth were selected and divided into three groups: group I “control group" untreated teeth; group II “medication group" subjected to oral pediatric medications Farcolin, Farcosolvin and Heamojet ; group III “treatment group" was treated with remineralizing pastes MI and MI plus after exposure to the different medications. Microhardness values were registered and selected specimens were imaged by SEM.
Results: There was a statistically significant difference (P<0.01) in microhardness values registered between control group (group I) and medication group (group II) and also between medication group (group II) and treatment group (group III). Images of SEM showed demineralization after usage of pediatric medications and remineralization after usage of remineralizing pastes.
Conclusions: The used oral pediatric medications had an erosive effect on the enamel surface, also in an in vitro model the use of a CPP-ACP and CPP-APF pastes had a protective effect on the demineralization of enamel.