Introduction: Saliva has been considered a valuable diagnostic tool for many disorders and diseases.
Objective: The aim of this study was to assess some important biomarkers of oxidative stress in the saliva of patients undergoing fixed orthodontic treatment.
Methods: A total of thirty three subjects (18 females and 15 males) in the age group of 15-18 years were enrolled in the study. The salivary samples were collected before fixed appliance placement, 6 months and 1 year after orthodontic treatment onset. Samples were investigated for measurement of malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxydeoxyguanosine (8-OHdG) levels.
Results: The salivary MDA, NO and 8-OHdG concentrations in the individuals treated with fixed orthodontic appliances did not show significant changes neither after 6 nor after 12 months of treatment compared to the basal values before treatment .
Conclusion: Fixed orthodontic therapy for one year did not induce oxidative damage in the oral cavity.