The purpose of this study was to evaluate the amount of released of silver and copper oxide nanoparticles when they were incorporated in heat cured acrylic resin denture, chemical cured soft liner, and cream type adhesive.
Material and methods: A total number of 240 samples were prepared, 80 denture base samples, 80 liner, and 80 adhesives, and 10 samples from each material were free from nanoparticles that act as a control. The remaining samples were divided into two groups: (Group I) contained denture base, liner and adhesive samples modified with copper-oxide nanoparticles concentration by (0.1%, 0.3%, and 0.5%, 10 sample each), and (Group II) has the same number of samples but modified with same silver nanoparticles concentrations. The samples were placed in distilled water for one week and the amount of release was measured by spectrophotometer. The recordings data were analyzed using Two-way repeated measures Analysis of Variance (ANOVA) to compare between the three groups as well as to study the effect of time within each group. Bonferroni's post-hoc test was used for pair-wise comparisons. P< 0.05 was considered.
Results: Release was higher in denture adhesive followed by denture liner and denture base respectively in the two groups. The amount of release increased with increasing nanoparticles concentration in denture base and adhesive but not in denture liner. There was no significant difference between Group I, and Group II.
Conclusion: Nanoparticle release was affected by the type of prosthetic material, nanoparticle concentration, but not nanoparticles type.