Aim: Comparing the cleanliness efficacy of Neolix and Silk nickel-titanium rotary systems used in root canal retreatment with and without Carvene solvent. Method: Forty extracted maxillary anterior teeth having single root canal were collected. Root canals were prepared and obturated with size 40 gutta-percha and Guttaflow bioseal, bioactive sealer. The root canals were distributed into two groups stated to the method of obturating material removal using (Neolix and Silk file systems). Further the groups were subdivided into two subgroups by using Carvene as a solvent or not. Roots were separated in bacco-lingual direction into two equal halves then cleanliness was analyzed using Stereomicroscope at the cervical, middle and apical regions. Results: Neolix system recorded higher cleanliness than Silk file system. Treatment with no-solvent recorded higher cleanliness than with using Carvene. Cervical region recorded the highest cleanliness followed by middle then apical region. Conclusion: Neolix file system without using solvent were more efficient for removing root canal obturating materials.