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72246

The effect of Erythropoietin on bone regeneration “an experimental study”

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Last updated: 22 Jan 2023

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Abstract

Background: Erythropoietin (EPO) is a hematopoietic growth factor stimulating the formation of red blood cells. EPO is notoriously known as a doping substance in high-performance sports, and in cycling in particular. In recent years, the non-hematopoietic functions of EPO, also known as pleiotropic functions which include osteogenic and angiogenic potencies have been intensively investigated.
Aim of study: The objectives of the present study were to address and investigate the efficacy of EPO in regenerating bone and facilitating bone healing by using a single local dose of 1ml EPO 4000 IU per animal to augments bony ingrowth in rabbit calvarial bony defect.
Material and methods: 12 New Zealand White rabbits received a calvarial defect. Absorbable oxidized cellulose was soaked with 1ml EPO 4000 IU (local treatment group) were implanted into the gap, the other side used as (control group). Histological analysis was performed 7, 14 and 30 days postoperatively. Vascularization was evaluated histologically.
Results: Histopathological findings of bone gap after 30 days of surgery, untreated animals showed granulation tissue which invaded numerous number of inflammatory cells mainly macrophages. Bony gap showed more fibrous tissue than fibrocartilage. In treated animals group, the periosteal cells proximal to the fracture gap developed into osteoblasts. The animals group, fracture induced gap was filled with well-organized bone trabeculae. The healed bone gap revealed numerous number of proliferative osteocytes .

DOI

10.21608/edj.2019.72246

Keywords

erythropoietin, Angiogenesis, osteogenesis, neovascularization

Authors

First Name

Nermine

Last Name

Mahmoud

MiddleName

Ramadan

Affiliation

Lecturer Oral and Maxillofacial Surgery, Oral Surgery Department, Faculty of Dentistry, October 6 University

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Volume

65

Article Issue

Issue 3 - July (Oral Surgery)

Related Issue

10697

Issue Date

2019-07-01

Receive Date

2020-02-19

Publish Date

2019-07-01

Page Start

2,199

Page End

2,208

Print ISSN

0070-9484

Online ISSN

2090-2360

Link

https://edj.journals.ekb.eg/article_72246.html

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https://edj.journals.ekb.eg/service?article_code=72246

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15

Type

Original Article

Type Code

254

Publication Type

Journal

Publication Title

Egyptian Dental Journal

Publication Link

https://edj.journals.ekb.eg/

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Article

Created At

22 Jan 2023