The Aim: of this study is to evaluate the efficacy of Reciproc and manual techniques with and without solvent for removing Real-Seal obturating system and Gutta-percha with resin sealer using Stereomicroscope. Methods: Eighty extracted mandibular premolars having single root canal were distributed into two groups stated on the obturation systems (Real-Seal obturating system and Gutta-percha with resin sealer) used. Then subdivided into two subgroups according to the method of obturating material removal (Reciproc and manual technique). Further subdivided into two classes by using solvent or not. Roots were separated in bacco-lingual direction into two equal halves then analyzed using Stereomicroscope at the cervical, middle and apical parts. Results: Reciproc system as retreatment instrument give the best result than manual instruments in removing both obturating material used (Real-Seal system and Gutta-Percha) and this was statistically significant. Without using solvent give the best result than using solvent in removing both obturating material used (Real-Seal system and Gutta-Percha) and this was statistically significant. Apical region recorded highest debris mean value followed by middle region while the lowest mean value recorded cervically and this was statistically significant. Conclusion: Reciproc system was more effective than manual instruments in removal of root canal obturating materials for endodontic retreatment.