Background: The aim was to compare the push-out bond strength of calcium silicate-based sealer Total Fill BC Sealer with an epoxy resin-based sealer Adseal used in cold lateral and single cone obturation techniques. Materials and Methods: Forty-eight single-rooted teeth with completely formed apices were selected. Teeth were decoronated, and working length was determined. Instrumentation and irrigation were performed. The teeth were equally and randomly divided into four groups (n=12) according to the obturation technique and the root canal sealer used as follow; Group I: Root canals were obturated using gutta percha & Totalfill bioceramic sealer by using single cone technique single cone technique, Group II: Root canals were obturated using gutta percha lateral condensation technique & Totalfill bioceramic sealer, Group III: Root canals were obturated using gutta percha & Adseal sealer by using single cone technique, and Group IV: Root canals were obturated using gutta percha & Adseal sealer by using lateral condensation technique. Manipulation and application of the sealer was done according the manufacturer instructions. All teeth were stored in an incubator at 37 °C and 100% humidity for 1 week to allow complete setting of the root canal sealers. Each root was prepared for push-out test using universal testing machine with root slices of 2 mm thickness were obtained at 3, 7, 11 mm from apex representing (apical, middle, and coronal) respectively, and the push-out bond strength was calculated. Statistical analysis was performed using One-way ANOVA followed by Tukey post hoc t-test was used to compare between more than two groups in non-related samples. Results: The highest bond strength was found in Group II (Totalfill & cold lateral obturation technique)
(P < 0.05) compared to other groups. The lowest bond strength was found in Group III (Adseal & single cone obturation technique). Conclusion: The push-out bond strength of Totalfill & Adseal root canal sealers with cold lateral obturation technique were highest followed by Totalfill& single cone technique and lowest bond strength was observed in Adseal & single cone on obturation technique. Higher push out bond strength values recorded in apical and middle thirds than coronal third.