Objectives: Our aim in the current study is to evaluate the level of high sensitivity C-reactive protein in serum of patients with periodontitis and type 2 diabetes before and after non-surgical periodontal treatment.
Subjects and methods: 60 individuals in total with stage II grade A generalized periodontitis (n=20) and stage II grade B generalized periodontitis with type 2 diabetes (n=20) along with healthy control subjects (n=20) were enrolled in this study. Serum samples from all participants were obtained. Two serum samples, before & after non-surgical periodontal treatment, were gathered from patients with periodontitis and periodontitis with type 2 diabetes. Only one serum sample was collected from healthy controls. Enzyme linked immunosorbent assay technique (ELISA) was used to measure serum levels of high sensitivity C-reactive protein (hs-CRP).
Results: The highest concentration of serum hs-CRP was detected in patients with periodontitis & type 2 diabetes. This is followed by periodontitis group and then controls subjects. A statistical significant reduction in the hs-CRP serum levels after non-surgical periodontal treatment was detected in periodontitis with diabetes group while the periodontitis group showed similar reduction but without statistical significance. High diagnostic accuracy of serum hs-CRP was revealed by the Receiver Operating Characteristic (ROC) curve analysis, especially when comparing periodontitis patients, with or without diabetes, with the control.
Conclusions: Serum hs-CRP could be utilized as a prognostic marker in patients with periodontitis and type 2 diabetes.