Introduction: Periostin is a matricellular protein highly expressed by the fibroblasts in the periodontal ligament. It is entangled in the maintenance of periodontal integrity which is affected by periodontal disease.
Aim: this study aimed to compare both GCF and salivary periostin levels during periodontal disease to their levels after non- surgical periodontal therapy.
Subjects and methods: The present study was performed on a total of 30 subjects, 13 males and 17 females. The thirty selected participants were sampled at baseline and after receiving the non-surgical periodontal treatment.
Results: In GCF, there was a statistically significant (at P ≤ 0.05) increase in mean Periostin level after treatment. While in saliva, there was a statistically significant (at P ≤0.05) decrease in mean Periostin level after treatment.
Conclusion Our results suggested that GCF periostin level may be considered as a reliable marker in the evaluation of periodontal disease activity, while salivary periostin level could have a promising diagnostic potential. So, further investigations are recommended.