The present study was designed to investigate the correlation between periodontitis and smoking status and secretory IgA level among a sample of Egyptian patients. The study was carried out on male subjects with age ranging from 25- 45 years . The subjects were divided to
3 groups of 30 subjects each ; Group I (Control group) subjects with no clinical and/or radiographic manifestations of periodontal disease and no history of smoking, Group II which includes subjects diagnosed of periodontitis with no history of smoking and Group III which includes subjects diagnosed of periodontitis with history of smoking. The level of salivary immunoglobulin A (SIgA) was measured for the three groups. The results of this study reported significant decrease in the level salivary immunoglobulin A (SIgA ) in group III compared to group I and II (P< 0.05)