Overall, the implementation of digital health information system in general and Electronic medical record (EMR) can improve quality of care, reduce cost in managing care environment and improve provider efficiency. EMR systems have the potential to provide clinical data essential for research. Objective:The main objective of this study was to develop a full automation of Research Institute of Ophthalmology(RIO) hospital through the detailed Hospital Management Information System implementation plan, and to build an information repository that includes all the information of patients attending RIO to be used in the purposes of scientific research and decision-making support.Method: The study relied on a comprehensive and detailed analysis method (Situation analysis) by combining observation, inquiry and personal interviews for direct access to information and building a system capable of addressing the problems and difficulties facing the Institute. Results: A large database containing the necessary information for each patient was established, that facilitated retrieval of essential data for patient care and conduction of research, reduction in paper costs, effort and time was also achieved and it insured protection and safety system for patient's medical information. Conclusion:Digital transformation is s a bright spot in the history of the Research Institute of Ophthalmology, which provides researchers with a huge information repository of eye diseases in Egypt through patients attending the institute's hospital. This project also represents a nucleus that can facilitate the hospital's connection to a future government health insurance project, which is expected to link the medical service to the patient's national number.