Background: Application of Evidence Based Medicine (EBM) is widely growing as a tool for the best available evidence in decision making in the health care. Objective: This study aims to assess knowledge, attitude and practice of resident physician towards EBM and to compare theses aspects between residents in a Teaching and a General Hospital in the same city and to determine their educational needs for greater use of EBM in health care. Method: This cross-sectional study included 522 residents from two hospitals. Data was collected using a self-administered questionnaire addressing knowledge, attitudes & practices about EBM and to define the barriers to practice it. Results: In most aspects, the knowledge, attitude and practice of Mansoura University Hospital residents about EBM was significantly higher than that for Mansoura General Hospital Conclusions: Although there is a high positive attitude among physicians towards EBM, the knowledge and the practice of EBM is still defective.