Objective: to assess medication adherence and quality of life (QoL) in children with asthma, to plan and implement an intervention to evaluate the outcome of patient centered care. Method: An interventional study was conducted on 82 children with asthma attending pediatric outpatient chest clinic at Zagazig University Hospitals. They were assigned into experimental or control groups randomly (41 patients in each). All patients, at first visit and after three months underwent assessment of medication adherence, inhaler technique and QoL, determination of asthma symptoms control and measuring pulmonary function. Experimental group only was subjected to face-to-face tailored patient education for about thirty minutes and follow-up visits every two weeks. Control group was subjected to routine clinical consultation Results: There was a highly significant improvement in all assessed variables among intervention group when compared with control group including QoL. The Experimental group had high medication adherence, accurate inhaler technique and, which were associated with well-controlled asthma. Conclusion: patient centered care approach to children with asthma and their caregivers could result in improving asthma outcomes in terms of medication adherence, asthma control and QoL.