Background: Nocturnal enuresis is a common pediatric disorder. It can be defined as the involuntary passage of urine during sleep beyond the age of anticipated nighttime bladder control. Nocturnal enuresis can have a serious effect on the quality of life of children and their families. Objective: to estimate the frequency and types of treatment of nocturnal enuresis among children aged (6–12) years in Minia city, as well as to identify some risk factors associated with this problem. Methods: A cross-sectional, community based study was done among primary school children aged (6-12); they were selected from Minia city in Minia governorate, representing the urban and rural areas. Results: 16.5% of children were suffering from primary nocturnal enuresis. As the age of the child increases, the prevalence of enuresis is significantly decreased. Enuresis is significantly more common among children whose fathers' occupation were clerical work, housewife mothers, and also more common among children of low socioeconomic status with no sex variation. Conclusion: Nocturnal enuresis is a pediatric public health problem; it is associated with younger age, low socioeconomic and low educational level of the parents, non-working mothers, and family history of enuresis. The most beneficial treatment measure was awaking the child to void and restricting fluid intake.