Background: The menopausal transition is a critical period in women's life; many physiological changes occur and cause morbidity to women at this stage. Women generally know very little about menopause, therefore, they should have knowledge about menopause. Objectives: to evaluate the effect of a health education program addressing the general health of menopausal women. Participants and method: An interventional study was carried out on 80 premenopausal female employees aged from 40 to 45 years at 10^th of Ramadan city schools by comparing pre-intervention with post-intervention questionnaire after a health education program which included questions to assess knowledge and attitude about menopause. Results:  there were statistically significant improvement of knowledge and attitude after the interventional program that corrected knowledge: being 51.3% among studied participants before the educational program and improved to 88.8% after the program and a positive attitude that changes from 6.3% before the program to 90% after the program. Conclusion and recommendation: This study concluded that health education about menopause improved knowledge and attitude of the studied women, so health education programs directed to menopause women need to be integrated within health care system.