Background: Chronic kidney disease (CKD) is a major health problem worldwide with increase morbidity and mortality and significant impact on patient quality of life (QoL) that is a main component of health outcome. In most of developing countries, the health related QoL gains less attention of health care providers. This needs more assessment to frame the rehabilitation and treatment programs and policies of chronic renal failure patients. General objective: to promote QoL of hemodialysis (HD) patients. Specific objectives to descube QoL among these patients. Methodology: The study is a cross section study conducted on patients with ESRD on regular HD at Talkha central hospital, Dakahlia Governorate, Egypt. Health related QoL (HRQoL) was assessed using the validated Kidney Disease QoL-Short Form (KDQOL-SF) tool. It includes one multi-item scale. Results: The patients' QOL scores were very low (below 50) for all subscales. The highest score was on social function (38.86±21 Range 25.0 - 87.5), physical function (33.87±13.76 Range 4.55 - 68.18) and Overall Health Rating (35.61±10.03 Range14.31- 61.15) were directing very weakly to the best and the lowest was on role of physical function (8.59 ± 21.46 Range 0 - 100), and Pain (17.18 ± 8.07Range 25.0 - 66.67) . Conclusion: Patients with ESRD on HD generally have a diminution reduction of their quality of life scores. The results of the study showed that there are no differences on QoL among male and female patients while age, occupation and presence of diabetes affect the total QoL score.