The aim of the study was to determine the frequency of erectile dysfunction among type 2 diabetes (T2DM) milletus and to determine the predictive risk factors of erectile dysfunction in men with T2DM. A cross-sectional study was conducted on 184 men with T2DM from patients attending the internal medicine diabetic outpatient clinic of Tanta university hospital, Gharbia Governorate, Egypt. The results revealed that 42.93% of study group suffered from erectile dysfunction. Glycated hemoglobin, age in years, systolic and diastolic blood pressure, smoking condition and high total cholesterol are considered significant predictors for erectile dysfunction among T2DM patients. The study concluded that the prevalence of erectile dysfunction was high in men with T2DM and glycated hemoglobin, age in years, systolic and diastolic blood pressure, smoking condition and high total cholesterol are considered significant predictive risk factors for erectile dysfunction among diabetic patients that let us recommend certain measures to prevent, early detection and management of these risk factors.