Introduction: Acute lymphocytic leukemia (ALL) is the most common malignancy in Egyptian children and has been among the 5 top prevalent pediatric cancers in Egypt, its proportion from total cancer cases is 6.4%. Objective: is to determine the effect of socioeconomic factors of the parents on the quality of life of leukemic children. Methods: Cross sectional study had been carried out at the national cancer institute in Cairo governorate, from July 2012 till January 2013 on 7-14 years old children. 388 recently diagnosed ALL children had been identified through reviewing the medical records from outpatient clinics of the national cancer institute in Cairo governorate; Demographic data had been collected from the parents of the child to get reliable information, as this kind of questions was too hard to a child to answer accurately, while data of the second section had been collected directly from the child. The first case was selected randomly then the third one was selected in randomly systematic way. Results: More than 80% of the study population belongs to low and very low social classes. The study shows there is statistically significant relation between the socioeconomic class and physical activity, child relation with his peers, and school progress quality of life domains. The most important predictor in SES was the income Conclusion: Most of the very low socioeconomic class children reported lower physical activity, social function, and school progress quality of life rather than low and middle socioeconomic class.