This study was conducted to investigate the effect of feeding three commercial feed additives Tonilisat® (Saccharomyces cerevisiae), Garlin® (26% allicin), Enziver® (Multi-enzymes) and different mixtures of them on growth performance, feed utilization, body composition and cost benefit of European eel (Anguilla anguilla) fry. A total of 160 European eel fry (3.0±0.2 g/fish) were divided into 8 groups (10 fish/tank in two replicates) for 120 days. Eight dietary treatments were conducted as follow: the first diet considered to be the control without any additives. The second and third diets contain 0.2% of Tonilisat® and Garlin®, respectively. The fourth diet contains 0.1% of Enziver®, The fifth diet contains a mixture of 0.1%  Tonilisat® with 0.1%  Garlin®, the sixth diet contains a mixture of 0.1% e Tonilisat® with 0.05%  Enziver®, the seventh diet contains a mixture of 0.1%  Garlin® with 0.05% Enziver®, and the eighth diet contains a mixture of 0.1%  Tonilisat® , 0.1%  Garlin® and  0.05% Enziver®, respectively. The obtained results indicated that growth performance, feed conversion ratio and nutrient utilization were significantly improved in eels fed diet supplemented with multi-enzymes and different mixtures of feed additives. The survival rate (%) and whole body proximate composition didn't differ significantly among different experimental groups. Meanwhile, the profit index improved significantly with multi-enzyme supplementation and the combinations of yeast, garlic and multi-enzyme increased diets benfits. Therefore, it's  reasonable  to incorporate exogenous multi-enzymes or combination of yeast, garlic and multi-enzyme in the diets of European eels.