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271284

A Diagnostic Dilemma of Encephalopathy in Acute Myeloid Leukemia Patient with Twice COVID-19 Infection: A Case Report

Article

Last updated: 01 Jan 2025

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Abstract

Background: During the COVID‐19 pandemic, there was limited data about the appropriate management of acute myeloid leukemia (AML) with COVID-19 infection and the possible post-COVID-19 complications reported in acute leukemia patients.
Case presentation: We report a 52-year-old lady with AML and confirmed twice SARS-CoV-2 infection. The first infection was just after the diagnosis of AML before the administration of induction therapy, and the second infection was just after she received the salvage therapy. The COVID-19 infection was confirmed by qRT-PCR and high-resolution non-contrast computerized tomography of the chest. Unfortunately, the patient developed post-covid neurological complications, disturbed consciousness level, and encephalopathy. The COVID-19 infection may have triggered encephalopathy or exaggerated the neurological toxicity of cytarabine even in a small dose. Another possible explanation is the exaggeration of cytokine storm by the administration of granulocyte-stimulating factors used in salvage therapy.
Conclusion: Management of COVID-19 infection in AML patients faces many challenges. These patients are more vulnerable and susceptible to many complications and high mortality rates. The treatment approach needs to be tailored to overcome the interaction between the treatment adverse events and the biology of covid-19 infection.

DOI

10.21608/resoncol.2022.167065.1176

Keywords

Acute Myeloid Leukemia, COVID-19, Encephalopathy

Authors

First Name

Reham

Last Name

Alghandour

MiddleName

-

Affiliation

Department of Medical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

rehamalghandour@mans.edu.eg

City

-

Orcid

0000-0002-9717-8504

First Name

Shaimaa

Last Name

El-Ashwah

MiddleName

-

Affiliation

Department of Clinical Hematology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

shaimaelashwah@gmail.com

City

Mansoura

Orcid

-

First Name

Ziad

Last Name

Emarah

MiddleName

-

Affiliation

Department of Medical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

ziadomara@gmail.com

City

Mansoura

Orcid

0000-0003-0622-2598

First Name

Salma

Last Name

Elashwah

MiddleName

-

Affiliation

Department of Medical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

salmasaber45@gmail.com

City

-

Orcid

-

First Name

Layla

Last Name

Saleh

MiddleName

M.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

laylasaleh@mans.edu.eg

City

-

Orcid

-

First Name

Marwa

Last Name

Elmaria

MiddleName

O.

Affiliation

Department of Chest Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

marwaomar@mans.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Ebrahim

MiddleName

A.

Affiliation

Department of Medical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

drmohamedawad@gmail.com

City

-

Orcid

-

First Name

Tawfik

Last Name

ElKhodary

MiddleName

-

Affiliation

Department of Medical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

tawragab2005@yahoo.com

City

-

Orcid

-

First Name

Gehad

Last Name

Saleh

MiddleName

A.

Affiliation

Department of Diagnostic and Interventional Radiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

gahmad1988@gmail.com

City

-

Orcid

-

First Name

Nada

Last Name

EL-Sheltawy

MiddleName

F.

Affiliation

Department of Medical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

nadaelsheltawy@gmail.com

City

-

Orcid

-

First Name

Heba

Last Name

Zaki

MiddleName

-

Affiliation

Department of Medical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

heba.elsandobi@gmail.com

City

-

Orcid

-

First Name

Sameh

Last Name

Shamaa

MiddleName

-

Affiliation

Department of Medical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

sameh.shamaa@yahoo.com

City

-

Orcid

-

Volume

18

Article Issue

2

Related Issue

37904

Issue Date

2022-12-01

Receive Date

2022-10-05

Publish Date

2022-12-01

Page Start

76

Page End

80

Print ISSN

2357-0687

Online ISSN

2357-0695

Article File

RESONCOL_Volume 18_Issue 2_Pages 76-80.pdf

PDF . 418.9kB

Link

https://resoncol.journals.ekb.eg/article_271284.html

Detail API

https://resoncol.journals.ekb.eg/service?article_code=271284

Order

5

Type

Case reports

Type Code

287

Publication Type

Journal

Publication Title

Research in Oncology

Publication Link

https://resoncol.journals.ekb.eg/

MainTitle

A Diagnostic Dilemma of Encephalopathy in Acute Myeloid Leukemia Patient with Twice COVID-19 Infection: A Case Report

Details

Type

Article

Created At

22 Jan 2023