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229208

A Review on the Dual Role of SOCS3 in Cancer

Article

Last updated: 22 Jan 2023

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Abstract

Background: Aberrant proliferation is a hallmark of cancer. Cellular proliferation mechanisms and various cytokines contribute to the progression of cancer. The tumor suppressor protein Suppressor of Cytokine Signalling 3 (SOCS3), which acts via the JAK/STAT pathway, have a role in the progression of cancer.
Aim: To explore the role of SOCS3 in all the hallmarks of cancer. To exhibit SOCS3 action on proliferation pathways and immune aspect affecting cancer progression.
Methods: The PubMed database was searched using the keywords proliferation, SOCS3, JAK/STAT, interleukins, and tumor suppressor. Articles relevant to SOCS3 were considered for this review.
Results: In this review, we have illustrated the dual action of SOCS3, which inhibits various proliferative mechanisms and affects certain interleukins that counterbalance the progression of cancer. In addition, SOCS3 affects all the hallmarks of cancer.
Conclusion: We hope that this review will stimulate further investigation of SOCS3, which has the potential to become a new target for the pharmacological treatment of various cancers in the future.

DOI

10.21608/resoncol.2022.114548.1159

Keywords

Cancer, SOCS3, JAK/STAT, Interleukins, proliferation

Authors

First Name

Rajdeep

Last Name

Chakraborty

MiddleName

-

Affiliation

Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia

Email

rajdeep.chakraborty@hdr.mq.edu.au

City

Sydney

Orcid

0000-0001-8210-0459

First Name

Charbel

Last Name

Darido

MiddleName

-

Affiliation

Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia , Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia

Email

charbel.darido@petermac.org

City

Melbourne

Orcid

0000-0002-6541-324X

First Name

Aziz

Last Name

Alnakli

MiddleName

A. A.

Affiliation

Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia

Email

aziz.alnakli@students.mq.edu.au

City

Sydney

Orcid

0000-0002-7385-0490

First Name

Honghua

Last Name

Hu

MiddleName

-

Affiliation

Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia

Email

helen.hu@mq.edu.au

City

Sydney

Orcid

0000-0002-3749-4089

First Name

Karen

Last Name

Vickery

MiddleName

-

Affiliation

Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia

Email

karen.vickery@mq.edu.au

City

Sydney

Orcid

0000-0003-0998-1370

Volume

18

Article Issue

1

Related Issue

35384

Issue Date

2022-06-01

Receive Date

2022-01-04

Publish Date

2022-06-01

Page Start

1

Page End

9

Print ISSN

2357-0687

Online ISSN

2357-0695

Link

https://resoncol.journals.ekb.eg/article_229208.html

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https://resoncol.journals.ekb.eg/service?article_code=229208

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1

Type

Review articles

Type Code

285

Publication Type

Journal

Publication Title

Research in Oncology

Publication Link

https://resoncol.journals.ekb.eg/

MainTitle

-

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Article

Created At

22 Jan 2023