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79331

Prognostic Value of CD56 Expression in Multiple Myeloma

Article

Last updated: 22 Jan 2023

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Abstract

Background: Understanding the prognostic markers of multiple myeloma (MM) helps in optimizing therapeutic approaches. CD56 is frequently expressed by malignant plasma cells and its use as a prognostic marker in MM is promising.
Aim: To evaluate prognostic value of CD56 expression in patients with MM.
Methods: This study included 50 newly diagnosed patients with MM. Bone marrow samples were analyzed for CD56 expression by flow cytometry. All patients received bortezomib-based therapy for at least 3-4 months.
Results: The median age of patients was 52 years (range 32-75) and 54% of them were males. The stage according to the International Staging System was I in 15 (30%) patients, II in 18 (36%) and III in 17 (34%). CD56 positivity was detected in 84% of enrolled patients. Multivariate analysis revealed that the lack of CD56 expression was an independent predictor of worse overall survival (HR = 4.31 [95% Confidence Interval: 1.23 – 15.13], p = 0.002).
Conclusion: The present study suggests that CD56 negativity is associated with poor prognosis in patients with MM and that its incorporation in the risk panel of MM may be considered. Further studies with larger sample size to validate its prognostic value are needed.

DOI

10.21608/resoncol.2020.24758.1091

Keywords

Multiple myeloma, Flow cytometry, CD56, prognosis

Authors

First Name

Salah

Last Name

Khallaf

MiddleName

M.

Affiliation

Medical Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

Email

salahmab76@yahoo.com

City

Assiut

Orcid

0000-0002-5189-9525

First Name

Eman

Last Name

Yousof

MiddleName

A.

Affiliation

Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

Email

d.emo24@yahoo.com

City

-

Orcid

-

First Name

Eman

Last Name

Ahmed

MiddleName

H.

Affiliation

Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

Email

ehasan888@gmail.com

City

Assiit

Orcid

-

First Name

Shymaa

Last Name

Mansor

MiddleName

G.

Affiliation

Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

Email

shymaagafar@yahoo.com

City

-

Orcid

-

First Name

Hanan

Last Name

Mohamed

MiddleName

O.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

hannahomar@yahoo.com

City

-

Orcid

-

First Name

Sahar

Last Name

Elgammal

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

s.elgammal@aun.edu.eg

City

-

Orcid

-

First Name

Sawsan

Last Name

Moeen

MiddleName

M.

Affiliation

Internal Medicine Department, Clinical Hematology Unit, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

sawsan.moeen@yahoo.com

City

-

Orcid

-

First Name

Doaa

Last Name

Sayed

MiddleName

M.

Affiliation

Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

Email

doaa.sayed123@gmail.com

City

-

Orcid

-

Volume

16

Article Issue

1

Related Issue

15020

Issue Date

2020-06-01

Receive Date

2020-02-26

Publish Date

2020-06-01

Page Start

6

Page End

10

Print ISSN

2357-0687

Online ISSN

2357-0695

Article File

RESONCOL_Volume 16_Issue 1_Pages 6-10.pdf

PDF . 208.6kB

Link

https://resoncol.journals.ekb.eg/article_79331.html

Detail API

https://resoncol.journals.ekb.eg/service?article_code=79331

Order

2

Type

Original Article

Type Code

200

Publication Type

Journal

Publication Title

Research in Oncology

Publication Link

https://resoncol.journals.ekb.eg/

MainTitle

-

Details

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Article

Created At

22 Jan 2023