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A Retrospective Study of Reirradiation for Patients with Locoregional Recurrent Head and Neck Cancer: A Single-Institution Experience

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Last updated: 01 Jan 2025

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Abstract

Aim: To assess the efficacy of reirradiation in locoregionally recurrent head and neck cancer (HNC) and to describe results in our center in relation to other published data among similar group of patients.
Methods: The medical records of 28 patients with HNC who received reirradiation with or without chemotherapy for loco-regional recurrence between 2005 and 2013 were reviewed. They were evaluated for; toxicity profile, overall survival (OS) and progression free survival (PFS).
Results: The median reirradiation dose was 50 Gy (range 40-60 Gy) and median radiation cumulative dose was 119 (range 113 -120). An overall response rate was seen in 36% of patients with only 3 patients showed complete response. The median OS was 9 months with 1-and 2-year survival rates being 34.1% and 10.6%. The OS and PFS were significantly better in patients who were treated with chemotherapy concomitant with radiation and received higher radiation dose. Grade 3 mucositis and skin reactions were seen in 24 % and 14% of patients, respectively. Conclusion: Reirradiation appears to be feasible in patients with recurrent HNC treated previously with radiation. The benefit of concurrent chemotherapy with reirradiation is expected. Our results are subject to limitations from the retrospective nature of the analysis, the relatively small number, and improper selection of patients.

DOI

10.21608/resoncol.2016.587

Keywords

Reirradiation, Recurrent head and neck cancer, Chemoradiotherapy

Authors

First Name

Dina

Last Name

Salem

MiddleName

-

Affiliation

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

dinasalem70@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Essa

MiddleName

-

Affiliation

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

dinasalem70@gmail.com

City

-

Orcid

-

First Name

Azza

Last Name

Adel

MiddleName

-

Affiliation

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

azzaadel69@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Refaa

MiddleName

-

Affiliation

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

refae-2020@gmail.com

City

-

Orcid

-

Volume

12

Article Issue

1

Related Issue

159

Issue Date

2016-06-01

Receive Date

2016-08-31

Publish Date

2016-06-01

Page Start

2

Page End

9

Print ISSN

2357-0687

Online ISSN

2357-0695

Article File

RESONCOL_Volume 12_Issue 1_Pages 2-9.pdf

PDF . 649.4kB

Link

https://resoncol.journals.ekb.eg/article_587.html

Detail API

https://resoncol.journals.ekb.eg/service?article_code=587

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2

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Original Article

Type Code

200

Publication Type

Journal

Publication Title

Research in Oncology

Publication Link

https://resoncol.journals.ekb.eg/

MainTitle

A Retrospective Study of Reirradiation for Patients with Locoregional Recurrent Head and Neck Cancer: A Single-Institution Experience

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Article

Created At

22 Jan 2023