In this study acute laminitis in foals has been diagnosed in Mosul city, Iraq through an investigating of 14 male foals, 12-14 months old, accidentally engorged with carbohydrates diet and five clinically healthy foals of the same age range were considered as the control group. Affected foals showed different clinical manifestations. Blood samples from diseased foals show a significant increase (p < 0.05) of Packed cells volume , total leukocyte count, and Neutrophils in affected foals in compare to control group. There was considerable difference indicated in clotting factor indices. Significant (p < 0.05) increase of Matrix Metalloproteinase is revealed in affected foals compared to control group. The histopathological features of affected foals show a hypertrophied disorganized structure like a teat shape of the secondary epidermal lamellae, while the tips of the primary epidermal lamella are separated from the basement membrane, however, the primary epidermal lamella cells are shapeless and collapsed from the basement membrane. Results of Radiographic examination indicated that the distal phalanx was significantly rotated from the hoof wall of the forelimbs, Furthermore, there is evidence of swelling of the heel region with the widening of coronary band accompanied by swelling of soft tissues and the distal phalanx slightly rotated from the hoof wall at the right and left hind limbs. It has been concluded that acute laminitis effectively and harmfully affects the sick animal, which may lead to a clear obstruction in walking movement and multiple health effects.