The disasters are competent for beginning the prevalence of waterborne infections. The earthquakes are the most important disaster worldwide. Studies have reported waterborne pathogens can causing about thirty-eight types of infections after each earthquake. Also, waterborne pathogens can cause a higher fatality than an earthquake. Therefore, a strategy for prevention from infections that may occur for people is important after each earthquake. Waterborne infections were sometimes causing two folds fatalities than the earthquake. Disasters are the most important complications in developing countries for the World Health Organization (WHO). Notably, occurrences of infectious diseases after natural disasters commonly occur, especially in seismic regions. Iran is located in the Alpine-Himalayan seismic belt and considered a seismic country. The planning of an infectious disease strategy is necessary for decreasing health problems. Therefore, our aims of the present study were to introduce important bacterial waterborne infectious agents that prevalence after the previous earthquakes and explained several important relevant prevention strategies.