The present study was carried out in order to evaluate the efficacy of xylazine (XYL), detomidine (DET) and romifidine (ROM) on analgesia, sedation and haematobiochemical parameters following epidural injection in Baladi Egyption goats. Six goats were used; treatment consists of 200µg/kg xylazine, 40µg/kg detomidine, 50µg/kg romifidine administrated in each group sequentially. Onset, duration and degree of analgesia, sedation and ataxia were recorded. Physical parameters (RR, RT, and HR), Hb, PCV%, DCL, serum glucose, urea, creatinine, ALT and AST were evaluated prior to injection and at 15, 45, 75,120 min after injection. Onset of analgesia after epidural DET was significantly earlier (1.00±0.28min). The duration of analgesia was significantly longer with ROM (140.00±1.15min). Analgesia and sedation scores were higher after administration of ROM. Duration of sedation was significantly longer with ROM (130.00±1.15min). The duration of ataxia was significantly shorter with DET (70.00±0.00min), with most delayed onset. It was noticed that RR, RT and HR tends to decrease overall at various treated groups compared to baseline levels. Hb and PCV were within the physiological limits in all groups. There was significant increase in blood glucose level after administration of all tested drugs. The BUN levels were decreased significantly with the administration of DETO and ROM. XYL produced a significant increase in creatinine and AST levels. ALT values significantly declined with XYL. In conclusion, Epidural administration of XYL, DET or ROM proved to be an effective analgesic and sedative agents for goats without severe adverse effect.