Background, Sedatives are usually prescribed for people who are anxious and worried, and have developed depression. The use of these drugs in the short term can have benefits, but their use in the long term may develop drug addiction. Therefore, research attempts are being made to identify a natural and effective drug source to discover and ultimately produce effective sedative drugs. The aim, The aim of this study was to report plant species in Shahrekord, Iran, that are used as sedatives by collecting local people's information about their properties and methods of use. Methods, This study was conducted in 2017 using face-to-face interviews and a questionnaire distributed among 29 traditional therapists in the region under purpose. The data drawn from the questionnaires were meticulously and appropriately tabulated, and finally analyzed by the Excel software. Results, According to the ethnobotanical knowledge in the studied region, medicinal plants Melissa officinalis,Hypericum scabrum L,Dracocephalum multicaule,Anchusa italyca Retz,Valeriana officinalis,Origanum vulgare L,Kelussia odoratissima,Tanacetum polycephal,Hyssopus augustifolia,Alcea spp,Dianthum capillus-veneris,Lavandula angustifolia are used as herbal sedatives. Conclusion, These plants might be used as alternative or complementary remedies and might be used for preparation of new drugs.