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Comparative assessment of the effect of Diminazene aceturate and Imidocarb dipropionate on haematology and serum biochemical parameters of apparently healthy Nigerian dogs.

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Last updated: 01 Jan 2025

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Abstract

Diminazene aceturate (DIAC) and Imidocarb diproprionate (IMD) are drugs of choice in the management of some heamoprotozoan diseases. In this study we evaluated the comparative effects of the two drugs on the haematology and serum biochemical parameters of Nigerian local dogs. Fifteen (15) apparently healthy Nigerian dogs were used in this study. Dogs were randomly divided into three equal groups. Group A received no treatment and served ascontrol. Groups B received intramuscular injection 3.5mg/kg DIAC and group C received 5.5 mg/kg of IMD via intramuscular injection. Blood samples were collected 24 hours after the administration of the drugs. through the cephalic vein from each dog for haematology and serum analysis. Packed cell volume (PCV), white blood cell (WBC), neutrophil, lymphocytes were counted. Serum aspartate aminotransferase (AST), alanine amino transferase (ALT), calcium, and chloride were measured. The overall results revealed that neither DIAC nor IMD treated groups caused any significant deviations from the untreated controls in all the above parameters assayed. In conclusion, both drugs are safe to use for treating heamoprotozoan diseases in the same dosage.

DOI

10.21608/ejvs.2018.2693.1028

Keywords

Diminazene aceturate, Imidocarb diproprionate, Blood protozoa, dogs, Biochemical changes, C.Bl. picture

Authors

First Name

Johnny

Last Name

Olukunle

MiddleName

O

Affiliation

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta. Ogun State, Nigeria.

Email

drfaks@yahoo.com

City

Abeokuta

Orcid

-

Volume

49

Article Issue

2

Related Issue

934

Issue Date

2018-12-01

Receive Date

2018-01-23

Publish Date

2018-12-01

Page Start

75

Page End

81

Print ISSN

1110-0222

Online ISSN

2357-089X

Article File

EJVS_Volume 49_Issue 2_Pages 75-81.pdf

PDF . 928.2kB

Link

https://ejvs.journals.ekb.eg/article_9499.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=9499

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Type

Original Article

Type Code

140

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Comparative assessment of the effect of Diminazene aceturate and Imidocarb dipropionate on haematology and serum biochemical parameters of apparently healthy Nigerian dogs.

Details

Type

Article

Created At

22 Jan 2023