THIS STUDY aimed to determine the changes in the hormonal and biochemical profile of pregnant dromedary camels to provide a baseline data under Egyptian climatic conditions. Blood samples were collected from15 pregnant she-camels aged 5-11 years old just postconception and thereafter monthly during gestation period and during periparturient period (at days 15, 7,4and 1prepartum,at parturition and at days 1, 4, 7 and 15 postpartum).Progesterone level increased significantly (P<0.05) after conception and during the1stand the 2ndtrimester of pregnancy then declined significantly (P<0.05) during the 3rd trimester. Meanwhile its level decreased significantly (P<0.05) during periparturient period. Cortisol level significantly (P<0.05) increased at the 3rd trimester and continued increasing significantly during prepartum period with a maximum level on the day of parturition after that it was markedly decreased during the few days postpartum to day 15 postpartum. Thyroid hormones levels were significant (P<0.05) decreased in their levels from early to late gestation then increased significantly (P<0.05) from day of parturition to day 15 postpartum. Total protein and albumin were significantly low (P<0.05) in the 2nd and the 3rd trimesters than the first one with no significance alterations in globulin levels. Total antioxidant, glutathione and ascorbic acid levels were lower in the 3rd trimester than others, whereas the levels were relatively low in prepartum than 15 days postpartum. Malondialdehyde concentration was significantly increased (P<0.05) during late pregnancy period as a result of the physiological stress of pregnancy