This investigation was conducted to assess the regulatory effect of hydrogen peroxide (H2O2) on the growth, development,yield and fruitquality of mango cv. Ewais grown under sandy soil during 2017 and 2018 seasons.The trees received five foliarsprays ofwater (control), 5, 10, 20 and 50 mM H2O2 under field conditions. Results showed that 5mM H2O2 treatment has significantly increasedtotal chlorophyll content of the leaves, fruit set / panicle, fruit retention/panicle, peel weight, pulp/fruitpercentage and reduced fruit drop of the fruits of mango (Mangifera indica linnaeus). Using 20 mM H2O2 was reasonable in enhancing vegetative growth (number of leaves / shoot and leaf area), resulting in large fruit length and fruit width, increasing number of fruits/ tree,fruit weight and yield as compared with control. Regarding to fruit quality, it was observed that the application with 20 mM H2O2 treatment significantly improved total sugar, phenol and carotenoids content. It wasconcluded that spraying 5 and 20 mM H2O2 once a week, two times before anthesis (5th of March and  13th of March) and eight times after anthesis (from 20th of April to 15th of June)maximized the yield, productivity and fruit quality of Mango fruits under field conditions.