Beta
196456

Reform of Hematopoietic, Apoptotic and Oxidative Disturbance Induced by Accumulated γ-irradiation in Rat’s Bone Marrow via Curative Efficacy of Bradykinin Potentiating Factor Isolated from Bee Venom

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

-

Abstract

BEE venom contains a strong bradykinin-potentiating factor (BPF). In previous studies, BPF isolated from scorpion venom has been shown to be protective against hepato- and nephrotoxicity by reducing oxidative stress. Therefore, the authors aimed at evaluating the novel ability of BPF isolated from bee venom in treating oxidative and apoptotic defects induced by accumulated doses of γ-irradiation in rat's bone marrow (BM). Rats were exposed to 8 Gy of γ-irradiation as accumulated doses and subsequently treated with BPF (1μg/g i.p.) aiming at elucidating the possibility of BPF to reduce irradiation harmful effects. The data obtained showed that the irradiated animals suffered from marked changes of many important hematopoietic parameters including red blood cells, white blood cells, platelets, viable bone marrow count, and serum hematopoietic growth factors as well as oxidative stress markers and apoptotic index in BM tissue. Interestingly, BPF was able to rescue the deleterious effects of irradiation in rats and normalized the aforementioned parameters to the basal levels.
In conclusion: The considerable amelioration of hematic morbidity, oxidative stress and apoptosis in BM exhibited new accomplishment to the BPF isolated from bee venom against accumulated irradiation defects.

DOI

10.21608/ejrsa.2021.89718.1121

Keywords

apoptosis, Bone marrow, BPF, Oxidative Stress, γ-irradiation

Authors

First Name

Hesham F.

Last Name

Hasan

MiddleName

-

Affiliation

Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt

Email

hes_fa@yahoo.com

City

cairo

Orcid

0000-0001-9647-2624

First Name

Shereen M.

Last Name

Galal

MiddleName

-

Affiliation

Health Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

Email

shereen.galal@yahoo.com

City

Cairo

Orcid

0000-0002-4359-7172

Volume

34

Article Issue

1

Related Issue

34615

Issue Date

2021-12-01

Receive Date

2021-08-08

Publish Date

2021-12-01

Page Start

11

Page End

19

Print ISSN

1110-0303

Online ISSN

2314-8527

Link

https://ejrsa.journals.ekb.eg/article_196456.html

Detail API

https://ejrsa.journals.ekb.eg/service?article_code=196456

Order

2

Type

Original Article

Type Code

136

Publication Type

Journal

Publication Title

Egyptian Journal of Radiation Sciences and Applications

Publication Link

https://ejrsa.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023