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67781

Effect of Clodronate Alone or in Combination with Vitamin E on Demineralization Induced by Whole Body Gamma Irradiation in Rats

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Last updated: 22 Jan 2023

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Abstract

BISPHOSPHONATES usually have been chosen in cancer treatment protocols for the management of fractures risk and controlling metastatic bone pain following chemo- and radiotherapy. This study aims at investigating the beneficial effect of clodronate alone or in combination with vitamin E in irradiated rats exposed to 1Gy 3 alternating days/week for 5 weeks. Calcitonin was also studied individually and in combination with vitamin E in order to investigate its possible effect on bone mass in irradiated rats. Irradiated rats treated with clodronate (5mg/kg, s.c., twice a week) or calcitonin (10 IU/kg, s.c., 48hrs) showed significant decreases in urinary hydroxyproline (Hpr), calcium (Ca) and significant increases in urinary phosphorus (Ph) and serum total antioxidant capacity (TAC) levels, while combination with vitamin E normalized most of measured parameters. It could be concluded that vitamin E could synergize the anti-osteoporotic effect of clodronate or calcitonin especially in γ- irradiated cases.

DOI

10.21608/ejrsa.2018.4850.1049

Keywords

Clodronate, Calcitonin, Vitamin E, γ- irradiation

Authors

First Name

Heba A.

Last Name

Gheita

MiddleName

-

Affiliation

Drug Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt

Email

hebagheita@hotmail.com

City

-

Orcid

-

First Name

Walaa A.

Last Name

Elsabbagh

MiddleName

-

Affiliation

Drug Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt

Email

walaaelsabbagh5@gmail.com

City

-

Orcid

-

First Name

Rania M.

Last Name

Abdelsalam

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Giza, Egypt

Email

rania.mohsen@pharma.cu.edu.eg

City

-

Orcid

-

First Name

Amina S.

Last Name

Attia

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Giza, Egypt

Email

amina.salim@pharma.cu.edu.eg

City

-

Orcid

-

First Name

Mona A.

Last Name

El-Ghazaly

MiddleName

-

Affiliation

Drug Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt

Email

monaghazaly@gmail.com

City

-

Orcid

-

Volume

32

Article Issue

2

Related Issue

11290

Issue Date

2019-12-01

Receive Date

2018-08-13

Publish Date

2019-12-01

Page Start

125

Page End

136

Print ISSN

1110-0303

Online ISSN

2314-8527

Article File

EJRSA_Volume 32_Issue 2_Pages 125-136.pdf

PDF . 2.3MB

Link

https://ejrsa.journals.ekb.eg/article_67781.html

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https://ejrsa.journals.ekb.eg/service?article_code=67781

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Original Article

Type Code

136

Publication Type

Journal

Publication Title

Egyptian Journal of Radiation Sciences and Applications

Publication Link

https://ejrsa.journals.ekb.eg/

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Article

Created At

22 Jan 2023