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23605

Biochemical Impacts of Treating Diabetic Rats with Irradiated Cinnamon

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Last updated: 22 Jan 2023

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Abstract

T HE OBJECTIVES of the present study are to evaluate the effect of γ-radiation on total phenolic contents of cinnamon dried powder (CDP) and also to investigate the role of raw and γ-irradiated cinnamon extract (CE) in ameliorating biological disturbances in alloxan-induced diabetic rats. The results obtained show that γ-irradiation (10kGy) increases the total phenolic contents of CDP by percent change 6.39%. The results revealed also that alloxan administration to rats (150mg/kg B.WT) showed a significant increase in the levels of serum glucose, urea, creatinine, uric acidconcomitant with a significant decrease in the levels of insulin, testosterone (T), serum total thyroid hormones triiodothyronin (T3) and thyroxine (T4). Furtherer more, alloxan induced asignificant elevation in lipid peroxidation and a reduction in glutathione content and antioxidant enzyme activities in the renal and testicular tissues of diabetic rats. Treatment of diabetic rats with either raw or γ-irradiated CE has significantly ameliorated the alteration in the antioxidant/oxidant status and improved hyperglycemia, renal, and endocrine abnormalities. In conclusion, the study indicated that cinnamon, in addition to being hypoglycaemic, is effective in reducing oxidative stress caused by alloxan-induceddiabetes and the γ-irradiation of CPE increased its hygienic quality and significantly its total phenolic content without a significant loss in its quality attributes.

DOI

10.21608/ejrsa.2018.6005.1055

Keywords

Cinnamon, antioxidants, diabetes, alloxan, Oxidative Stress, gamma radiation

Authors

First Name

Mohamed

Last Name

Abd el-Megid

MiddleName

-

Affiliation

Natural Products Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt

Email

hassan.m3231@yahoo.com

City

cairo

Orcid

-

First Name

Ashraf

Last Name

Mounir

MiddleName

-

Affiliation

Food Irradiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), Cairo, Egypt

Email

ash1810@hotmail.com

City

Cairo, Egypt

Orcid

-

First Name

A.

Last Name

Abdul Azeem

MiddleName

-

Affiliation

Food irradiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), Cairo, Egypt

Email

alyncrrt@yahoo.com

City

Cairo

Orcid

-

First Name

A.

Last Name

el-Shahat

MiddleName

-

Affiliation

Food irradiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), Cairo, Egypt

Email

amrnagh.4a@yahoo.com

City

cairo

Orcid

-

Volume

31

Article Issue

2

Related Issue

5008

Issue Date

2018-12-01

Receive Date

2018-10-31

Publish Date

2018-12-01

Page Start

195

Page End

204

Print ISSN

1110-0303

Online ISSN

2314-8527

Article File

EJRSA_Volume 31_Issue 2_Pages 195-204.pdf

PDF . 619.9kB

Link

https://ejrsa.journals.ekb.eg/article_23605.html

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https://ejrsa.journals.ekb.eg/service?article_code=23605

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Original Article

Type Code

136

Publication Type

Journal

Publication Title

Egyptian Journal of Radiation Sciences and Applications

Publication Link

https://ejrsa.journals.ekb.eg/

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Article

Created At

22 Jan 2023