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14032

ESR Studies on Characteristic Physio-chemical Effects of Some Irradiated Antibiotics

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Last updated: 22 Jan 2023

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Abstract

MOST of the characteristic chemical effects of the irradiated solid drugs are not accurately detected by the conventional tests such as ultra violet spectro-photometry and melting point technique. Sterilization using gamma irradiation is a desirable alternative for the thermo-sensitive drugs. Antibiotics samples were -irradiated at room temperature with doses ranging from 2 kGy up to 25 kGy. Electron Spine Resonance (ESR) measurements were applied on four types of antibiotics; Amoxycillin, Ampicillin, Dalacin and Spiramycin (AMX, AMP, DAL and SPI). ESR results exhibited the impact of irradiation and storage parameters on the nature and concentration of the trapped radicals. The radical concentration is directly proportional to the ESR peak height signal also depending on the absorbed dose delivered to the antibiotic samples. The obtained information about the irradiated radiolytic products was found to verify the radical mechanisms. This information may be used to detect an irradiation treatment on such pharmaceuticals.

DOI

10.21608/ejrsa.2018.3021.1040

Keywords

Drug sterilization, ESR, Ionizing radiation, Gamma Irradiation

Authors

First Name

Saleh

Last Name

Abdou

MiddleName

-

Affiliation

Radiation Physics Department, NCRRT, Atomic Energy Authority (AEA), Cairo, Egypt

Email

salehabdou03@yahoo.com

City

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Orcid

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First Name

S.

Last Name

Ebraheem

MiddleName

-

Affiliation

Radiation Protection Department, NCRRT, Atomic Energy Authority (AEA), Cairo, Egypt

Email

seif_dose@yahoo.com

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-

Orcid

-

Volume

31

Article Issue

2

Related Issue

5008

Issue Date

2018-12-01

Receive Date

2018-02-25

Publish Date

2018-12-01

Page Start

137

Page End

142

Print ISSN

1110-0303

Online ISSN

2314-8527

Article File

EJRSA_Volume 31_Issue 2_Pages 137-142.pdf

PDF . 764.3kB

Link

https://ejrsa.journals.ekb.eg/article_14032.html

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https://ejrsa.journals.ekb.eg/service?article_code=14032

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Original Article

Type Code

136

Publication Type

Journal

Publication Title

Egyptian Journal of Radiation Sciences and Applications

Publication Link

https://ejrsa.journals.ekb.eg/

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Article

Created At

22 Jan 2023