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<i>Panax ginseng </i> Extract Modulates Cerebral Damage Caused by Gamma Irradiation in Male Albino Rats

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Last updated: 22 Jan 2023

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Abstract

THIS STUDY is designed to investigate the protective effect of aqueous Panax ginseng extract against acute brain damage induced by gamma irradiation in rats. Animals were sacrificed 24h post-whole body gamma irradiation (6Gy). The results revealed oxidative injury denoted by a significant increase in the levels of malondialdehyde (MDA) associated to a significant decrease in the level of reduced glutathione (GSH), and superoxide dismutase (SOD) and catalase (CAT) activities in brain tissues. The administration of Panax ginseng at a dose of 100mg/kg body weight for 7 consecutive days before irradiation has significantly attenuated the severity of oxidative stress. Furthermore, Panax ginseng has significantly improved the decrease recorded in the level of the neurotransmitters serotonin (5-HT), dopamine (DA), norepinephrine (NE) and acetylcholine (Ach) induced by gamma irradiation in brain tissue. The oral administration of ginseng extract prior to irradiation has attenuated also a significant decrease in serum asymmetric dimethyl arginine (ADMA) as well as a significant increase in serum nitric oxide (NO) compared with the irradiated group. The histopathological and immunohistochemical examination substantiate the aforementioned amelioration in the biochemical parameters. In conclusion, the Panax ginseng extract might alleviate the oxidative brain damage and the alteration of neurotransmitters induced by gamma-irradiation in rats.

DOI

10.21608/ejrsa.2018.2008.1032

Keywords

<i> Panax ginseng </i>, Gamma Irradiation, Oxidative Stress, neurotransmitters

Authors

First Name

Shereen

Last Name

Elkiki

MiddleName

-

Affiliation

Health Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), PO Box 29, Nasr City, Cairo, Egypt

Email

shereenelkiki@yahoo.com

City

Cairo,Egypt

Orcid

-

First Name

Shereen

Last Name

Galal

MiddleName

-

Affiliation

Health Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), PO Box 29, Nasr City, Cairo, Egypt

Email

shereen.galal@yahoo.com

City

Cairo

Orcid

0000-0002-4359-7172

Volume

31

Article Issue

2

Related Issue

5008

Issue Date

2018-12-01

Receive Date

2017-11-21

Publish Date

2018-12-01

Page Start

111

Page End

124

Print ISSN

1110-0303

Online ISSN

2314-8527

Article File

EJRSA_Volume 31_Issue 2_Pages 111-124.pdf

PDF . 2.2MB

Link

https://ejrsa.journals.ekb.eg/article_5860.html

Detail API

https://ejrsa.journals.ekb.eg/service?article_code=5860

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3

Type

Original Article

Type Code

136

Publication Type

Journal

Publication Title

Egyptian Journal of Radiation Sciences and Applications

Publication Link

https://ejrsa.journals.ekb.eg/

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Article

Created At

22 Jan 2023