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4713

Activation Role of Low Dose Ionizing Radiation on Human Lymphocytes Response

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Last updated: 22 Jan 2023

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Abstract

LOW dose ionizing radiation can imitate the role of deteriorate antigen or attenuated microbes as it activates the first defence line of immune response, the step which when lost, cancer cells can find suitable environmental condition for growth propagation. Human whole blood samples were irradiated in vitro at doses (0.25, 0.5, 0.75 and 1Gy) of ionizing radiation and then kept at 37oC for 1h before measuring glucose concentrations which reflect the maximum activation of immune cells. Then, immunological parameters such as interlukine-1β (IL-1β), interlukine-2 (IL-2), transforming growth factor beta (1) (TGF-β1) were investigated. Also, inflammatory mediators as intracellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and tyrosine kinase activity were determined. Low doses of ionizing radiation induced slight activation of the immune cell cytokines (IL-1β and TGF-β1), inflammatory mediators (ICAM, VCAM) and tyrosine kinase activity at doses (0.25, 0.5Gy) reaching to significant levels at 0.75Gy and 1Gy. While, IL-2 and glucose levels were significantly decrease.

DOI

10.21608/ejrsa.2017.1816.1022

Keywords

Gmama-irradiation, IL-1β, IL-2, TGF-β, ICAM and VCAM

Authors

First Name

Sherien

Last Name

Montaser

MiddleName

-

Affiliation

Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P. O. Box: 29 Nasr City, Egypt

Email

sherien_morsy@yahoo.com

City

Cairo

Orcid

0000-0001-8033-1018

First Name

Gehan

Last Name

Roshdy Abdel Hamid

MiddleName

-

Affiliation

Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P. O. Box: 29 Nasr City, Egypt

Email

gih_ro@yahoo.com

City

-

Orcid

-

First Name

Ahmad

Last Name

Rashad Aboghadeer

MiddleName

-

Affiliation

Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P. O. Box: 29 Nasr City, Egypt

Email

ahmedaboghadeer@hotmail.com

City

-

Orcid

null

Volume

31

Article Issue

2

Related Issue

5008

Issue Date

2018-12-01

Receive Date

2017-10-10

Publish Date

2018-12-01

Page Start

89

Page End

95

Print ISSN

1110-0303

Online ISSN

2314-8527

Article File

EJRSA_Volume 31_Issue 2_Pages 89-95.pdf

PDF . 527.6kB

Link

https://ejrsa.journals.ekb.eg/article_4713.html

Detail API

https://ejrsa.journals.ekb.eg/service?article_code=4713

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Original Article

Type Code

136

Publication Type

Journal

Publication Title

Egyptian Journal of Radiation Sciences and Applications

Publication Link

https://ejrsa.journals.ekb.eg/

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Article

Created At

22 Jan 2023