Aim: To determine the association of adipokynes like Leptin, Ghrelin, antioxidants as SOD, Glutathione, peroxidase and iron overload and their effect on growth and on bone mineral density in patients with thalassemia major
Methods: 30 patients and 30 healthy age and sex matched controls from the hematology clinic hospital, Cairo University. Clinical examination and the anthropometric measurements are done in all subjects. Bone mineral density is assessed using DXA machine on lumbar spine expressed in Z Score Laboratory investigations, including super oxide dismutase (SOD) and Glutathione peroxidase.
Results: The study showed that there was a significant difference between cases and controls regarding BMI, Leptin, Ghrelin, BMD, SOD and glutathione peroxides with p- values 0.003,