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RREAST CANCER is one of the most common malignancies among women in the world and is a leading cause of morbidity and mortality in females of both developed and developing countries. The present work aimed to study the diagnostic value of prostate specific antigen (PSA) for breast cancer and the importance of treatment by blue green algae Spirulina platensis supplementation on PSA and testosterone levels. Two different analytical techniques based on micro particle enzyme immunoassay (MPIA) and enzyme linked fluorescent assay (ILFA) for quantitative determination of total PSA (free PSA and PSA complexed to alpha-1-antichymptrypsin) were studied in the diagnosis of breast cancer before and after Spirulina platensis supplementation.
Female rats secret PSA from female prostate gland, serum testosterone and PSA concentrations were not detected in control and rats supplemented by
Spirulina platensis groups.
Serum testosterone and PSA concentration were significantly higher (
P< 0.05) in rats bearing mammary tumours than rats bearing mammary tumours supplemented with Spirulina platensis. These results suggest that the clinical applicability of total PSA for breast cancer diagnosis and the biological mechanism behind its increase should be further investigated. Finally, the physiological mechanism behind the total PSA increase in breast cancer and its ramifications with respect to tumour progression should be further investigated.
DOI
10.21608/ejrsa.2013.1500
Keywords
testosterone, prostate specific antigen, breast cancer, female rats
Link
https://ejrsa.journals.ekb.eg/article_1500.html
Detail API
https://ejrsa.journals.ekb.eg/service?article_code=1500
Publication Title
Egyptian Journal of Radiation Sciences and Applications
Publication Link
https://ejrsa.journals.ekb.eg/
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