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Ellagic Acid and Zinc Aspartate Ameliorate Gamma Radiation Induced Biochemical Alterations in Male Rats

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Last updated: 01 Jan 2025

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Abstract

 THIS STUDY was designed to investigate the protective effect of oral administration of ellagic acid (EA), a natural polyphenol (50mg/kg body wt) and/or zinc aspartate (ZA) (50mg/kg body wt) against the cellular damage induced by whole body gamma irradiation (6.5Gy as a single dose) in male albino rats. The results of the current study revealed that exposure to γ-radiation exhibited a potential elevation of serum iron, total iron binding capacity (TIBC) and transferrin; as well as lipid peroxidation (LPO) and metallothioneins (MTs) in liver and kidney. In addition, there were significant decrease in superoxide dismutase (SOD) and reduced glutathione (GSH). In addition, tissues of liver and kidney displayed changes in some trace elements concentrations. Rats treated with EA and/or ZA before and after whole body γ-irradiation revealed significant modulation of the biochemical parameters and improvement in the antioxidant status, which might be effective in minimizing the radiation-induced increase in LPO as well as changes in essential trace elements in liver and kidney tissues reflecting a synergistic effect.

DOI

10.21608/ejrsa.2013.1498

Keywords

Ellagic acid, zinc aspartate, γ-radiation, Rats

Volume

26

Article Issue

1

Related Issue

321

Issue Date

2013-12-01

Receive Date

2013-12-09

Publish Date

2013-12-31

Page Start

71

Page End

84

Print ISSN

1110-0303

Online ISSN

2314-8527

Article File

EJRSA_Volume 26_Issue 1_Pages 71-84.pdf

PDF . 522.0kB

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https://ejrsa.journals.ekb.eg/article_1498.html

Detail API

https://ejrsa.journals.ekb.eg/service?article_code=1498

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6

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Original Article

Type Code

136

Publication Type

Journal

Publication Title

Egyptian Journal of Radiation Sciences and Applications

Publication Link

https://ejrsa.journals.ekb.eg/

MainTitle

Ellagic Acid and Zinc Aspartate Ameliorate Gamma Radiation Induced Biochemical Alterations in Male Rats

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Article

Created At

22 Jan 2023