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Possible Role of γ-Irradiated Ginseng in the Modulation of Some Biochemical Disorders Produced by Aluminum in Rats

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Last updated: 01 Jan 2025

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Abstract

 ALUMINUM (Al) toxicity in human and animals has been a matter of concern. Ginseng is liable to be contaminated by micro-organisms during the pre- and post-harvest handlings. Thus, ginseng decontamination by γ- rays is needed to warrant the microbiological quality. The aim of this study is to demonstrate the protective effect of γ-irradiated ginseng against Al-induced toxicity in rat model. Male albino rats were divided into four groups of 8 rats : A control group, the γ- irradiated ginseng extract (IGE) group; daily received the IGE (400 mg kg-1 body wt) for 6 weeks, the Al group received orally a daily dose (0.5 mg kg-1 body wt) of aluminum chloride (AlCl3) for 6 weeks and the irradiated ginseng extract+ AlCl3 (IGE-Al) group, received IGE+ AlCl3 for 6 weeks. Al administration significantly decreased some haematological parameters, sex hormones. Antioxidant enzymes activity in liver and testes showed a decrease. The results also showed a significant increase in some hepatic marker enzymes associated with an elevation of tissue lipid peroxidation (LPO). When experimental animals received IGE+ ALCL3, all these parameters were restored to approximately the control levels. These results demonstrated that administration of γ-irradiated ginseng could be effective in the protection against the toxicity of AlCl3.

DOI

10.21608/ejrsa.2011.1482

Keywords

Aluminum, Ginseng, Radiation, Oxidative Stress, antioxidants

Volume

24

Article Issue

2

Related Issue

317

Issue Date

2011-12-01

Receive Date

2012-06-14

Publish Date

2011-12-31

Page Start

373

Page End

385

Print ISSN

1110-0303

Online ISSN

2314-8527

Article File

EJRSA_Volume 24_Issue 2_Pages 373-385.pdf

PDF . 446.0kB

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https://ejrsa.journals.ekb.eg/article_1482.html

Detail API

https://ejrsa.journals.ekb.eg/service?article_code=1482

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13

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Original Article

Type Code

136

Publication Type

Journal

Publication Title

Egyptian Journal of Radiation Sciences and Applications

Publication Link

https://ejrsa.journals.ekb.eg/

MainTitle

Possible Role of γ-Irradiated Ginseng in the Modulation of Some Biochemical Disorders Produced by Aluminum in Rats

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Article

Created At

22 Jan 2023